TY - JOUR
T1 - Inflammatory Polymorphisms (IL-6 rs1800796, IL-10 rs1800896, TNF-α rs1800629, and IFITM3 rs12252) Are Not Associated with Post-COVID Symptoms in Previously Hospitalized COVID-19 Survivors
AU - Fernández-de-Las-Peñas, César
AU - Díaz-Gil, Gema
AU - Gil-Crujera, Antonio
AU - Gómez-Sánchez, Stella M
AU - Ambite-Quesada, Silvia
AU - Torres-Macho, Juan
AU - Ryan-Murua, Pablo
AU - Franco-Moreno, Ana I
AU - Pellicer-Valero, Oscar J
AU - Arendt-Nielsen, Lars
AU - Giordano, Rocco
PY - 2024/2/9
Y1 - 2024/2/9
N2 - The aim of this study was to identify the association between four selected inflammatory polymorphisms with the development of long-term post-COVID symptoms in subjects who had been hospitalized due to SARS-CoV-2 infection during the first wave of the pandemic. These polymorphisms were selected as they are associated with severe COVID-19 disease and cytokine storm, so they could be important to prognoses post-COVID. A total of 408 (48.5% female, age: 58.5 ± 14.0 years) previously hospitalized COVID-19 survivors participated. The three potential genotypes of the following four single-nucleotide polymorphisms, IL-6 rs1800796, IL-10 rs1800896, TNF-α rs1800629, and IFITM3 rs12252, were obtained from non-stimulated saliva samples of the participants. The participants were asked to self-report the presence of any post-COVID symptoms (defined as symptoms that had started no later than one month after SARS-CoV-2 acute infection) and whether the symptoms persisted at the time of the study. At the time of the study (mean: 15.6, SD: 5.6 months after discharge), 89.4% of patients reported at least one post-COVID symptom (mean number of symptoms: 3.0; SD: 1.7). Fatigue (69.3%), pain (40.9%), and memory loss (27.2%) were the most prevalent post-COVID symptoms in the total sample. Overall, no differences in the post-COVID symptoms depending on the IL-6 rs1800796, IL-10 rs1800896, TNF-α rs1800629, and IFITM3 rs12252 genotypes were seen. The four SNPs assessed, albeit having been previously associated with inflammation and COVID-19 severity, did not cause a predisposition to the development of post-COVID symptoms in the previously hospitalized COVID-19 survivors.
AB - The aim of this study was to identify the association between four selected inflammatory polymorphisms with the development of long-term post-COVID symptoms in subjects who had been hospitalized due to SARS-CoV-2 infection during the first wave of the pandemic. These polymorphisms were selected as they are associated with severe COVID-19 disease and cytokine storm, so they could be important to prognoses post-COVID. A total of 408 (48.5% female, age: 58.5 ± 14.0 years) previously hospitalized COVID-19 survivors participated. The three potential genotypes of the following four single-nucleotide polymorphisms, IL-6 rs1800796, IL-10 rs1800896, TNF-α rs1800629, and IFITM3 rs12252, were obtained from non-stimulated saliva samples of the participants. The participants were asked to self-report the presence of any post-COVID symptoms (defined as symptoms that had started no later than one month after SARS-CoV-2 acute infection) and whether the symptoms persisted at the time of the study. At the time of the study (mean: 15.6, SD: 5.6 months after discharge), 89.4% of patients reported at least one post-COVID symptom (mean number of symptoms: 3.0; SD: 1.7). Fatigue (69.3%), pain (40.9%), and memory loss (27.2%) were the most prevalent post-COVID symptoms in the total sample. Overall, no differences in the post-COVID symptoms depending on the IL-6 rs1800796, IL-10 rs1800896, TNF-α rs1800629, and IFITM3 rs12252 genotypes were seen. The four SNPs assessed, albeit having been previously associated with inflammation and COVID-19 severity, did not cause a predisposition to the development of post-COVID symptoms in the previously hospitalized COVID-19 survivors.
KW - Adult
KW - Aged
KW - COVID-19/genetics
KW - Female
KW - Humans
KW - Interleukin-10/genetics
KW - Interleukin-6/genetics
KW - Male
KW - Membrane Proteins/genetics
KW - Middle Aged
KW - Polymorphism, Single Nucleotide
KW - RNA-Binding Proteins/genetics
KW - SARS-CoV-2/genetics
KW - Tumor Necrosis Factor-alpha/genetics
KW - IFITM3
KW - single-nucleotide polymorphism, IL-6
KW - genotypes
KW - IL-10
KW - TNF-α
KW - post-COVID
UR - http://www.scopus.com/inward/record.url?scp=85186747880&partnerID=8YFLogxK
U2 - 10.3390/v16020275
DO - 10.3390/v16020275
M3 - Journal article
C2 - 38400050
SN - 1999-4915
VL - 16
JO - Viruses
JF - Viruses
IS - 2
M1 - 275
ER -