TY - JOUR
T1 - Headache as a COVID-19 onset symptom or Post-COVID symptom according to the SARS-CoV-2 Variant
AU - Fernández-de-Las-Peñas, César
AU - Cuadrado, Maria L
AU - Gómez-Mayordomo, Victor
AU - García-Azorín, David
AU - Arendt-Nielsen, Lars
PY - 2023
Y1 - 2023
N2 - INTRODUCTION: COVID19 associated headaches are highly common and there is currently an unmet need to better understand their association with SARSCoV2 variants. Headaches are a prevalent symptom in the acute phase of COVID19 and are associated with a better prognosis and better immune response. They are also a relevant post-COVID symptom.AREAS COVERED: This article analyses the differences in the prevalence of headache as an onset symptom and in post-COVID headache among the different SARS-CoV-2 variants: the historical strain, Alpha, Delta and Omicron. The different pathophysiological mechanisms by which SARS-CoV-2 infection may cause headache are also discussed.EXPERT OPINION: The presence of headache at the acute phase is a risk factor for post-COVID headache, whereas a history of primary headache does not appear to be associated with post-COVID headache. The prevalence of headache as an onset symptom appears to be variable for the different SARS-CoV-2 variants, but current data are inconclusive. However, the current evidence also suggests that headache represents a prevalent symptom in the acute and post-infection COVID-19 phase, regardless of SARS-CoV-2 variant.
AB - INTRODUCTION: COVID19 associated headaches are highly common and there is currently an unmet need to better understand their association with SARSCoV2 variants. Headaches are a prevalent symptom in the acute phase of COVID19 and are associated with a better prognosis and better immune response. They are also a relevant post-COVID symptom.AREAS COVERED: This article analyses the differences in the prevalence of headache as an onset symptom and in post-COVID headache among the different SARS-CoV-2 variants: the historical strain, Alpha, Delta and Omicron. The different pathophysiological mechanisms by which SARS-CoV-2 infection may cause headache are also discussed.EXPERT OPINION: The presence of headache at the acute phase is a risk factor for post-COVID headache, whereas a history of primary headache does not appear to be associated with post-COVID headache. The prevalence of headache as an onset symptom appears to be variable for the different SARS-CoV-2 variants, but current data are inconclusive. However, the current evidence also suggests that headache represents a prevalent symptom in the acute and post-infection COVID-19 phase, regardless of SARS-CoV-2 variant.
KW - COVID-19
KW - Headache
KW - SARS-CoV-2
KW - long COVID
KW - post-COVID
KW - variant
UR - http://www.scopus.com/inward/record.url?scp=85149362267&partnerID=8YFLogxK
U2 - 10.1080/14737175.2023.2185138
DO - 10.1080/14737175.2023.2185138
M3 - Review article
C2 - 36857191
SN - 1473-7175
VL - 23
SP - 179
EP - 186
JO - Expert Review of Neurotherapeutics
JF - Expert Review of Neurotherapeutics
IS - 2
ER -